Document Type
Article
Publication Date
3-7-2018
Identifier
DOI https://doi.org/10.2147/RRN.S125758
Abstract
Acute bilirubin encephalopathy (ABE) remains a significant cause of morbidity and mortality throughout the world, especially in low-middle-income countries where it can account for up to 15% of neonatal death. The pathophysiology of this acute life-threatening event of infancy and its potential evolution to kernicterus remain poorly understood. In this review, we start by reviewing the terminology of hyperbilirubinemia and its clinical consequences, ABE and later kernicterus spectrum disorder (KSD). We then review the pathogenesis of ABE and discuss clinical factors that can contribute to its pathogenicity. We examine in detail the clinical correlates of ABE and KSD. We present a comprehensive approach to its diagnosis and conclude with a set of simple clinical interventions ranging between primary preventive and rehabilitative measures that may help reduce the incidence of this largely preventable disease.
Journal Title
Research and Reports in Neonatology
Volume
8
First Page
33
Last Page
44
Keywords
acute bilirubin encephalopathy, neonatal jaundice, kernicterus, kernicterus spectrum disorder, low-middle-income countries
Recommended Citation
Usman F, Diala UM, Shapiro SM, Le Pichon JB, Slusher TM. Acute bilirubin encephalopathy and its progression to kernicterus: current perspectives. Research and Reports in Neonatology. 2018;8:33-44 https://doi.org/10.2147/RRN.S125758
Included in
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Neurology Commons, Pediatrics Commons
Comments
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Publisher's Link: https://www.dovepress.com/acute-bilirubin-encephalopathy-and-its-progression-to-kernicterus-curr-peer-reviewed-fulltext-article-RRN