The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study.

Document Type

Article

Publication Date

12-2014

Identifier

DOI: 10.1007/s10461-014-0905-x; PMCID: PMC4495040

Abstract

In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

Journal Title

AIDS and behavior

Volume

18

Issue

12

First Page

2285

Last Page

2290

MeSH Keywords

Adult; Aged; Anti-HIV Agents; Female; HIV Infections; HIV-1; Health Promotion; Humans; Male; Medication Adherence; Middle Aged; Program Evaluation; Reproducibility of Results; Self Report; United States; Viral Load

Keywords

Anti-HIV Agents; HIV Infections; HIV-1; Health Promotion; Medication Adherence; Program Evaluation; Reproducibility of Results; Self Report; United States; Viral Load

Comments

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