The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study.
DOI: 10.1007/s10461-014-0905-x; PMCID: PMC4495040
In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes , electronically monitored adherence and  viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.
AIDS and behavior
Adult; Aged; Anti-HIV Agents; Female; HIV Infections; HIV-1; Health Promotion; Humans; Male; Medication Adherence; Middle Aged; Program Evaluation; Reproducibility of Results; Self Report; United States; Viral Load
Anti-HIV Agents; HIV Infections; HIV-1; Health Promotion; Medication Adherence; Program Evaluation; Reproducibility of Results; Self Report; United States; Viral Load
Simoni, J. M., Huh, D., Wang, Y., Wilson, I. B., Reynolds, N. R., Remien, R. H., Goggin, K., Gross, R., Rosen, M. I., Schneiderman, N., Arnsten, J., Golin, C. E., Erlen, J. A., Bangsberg, D. R., Liu, H. The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study. AIDS and behavior 18, 2285-2290 (2014).