Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

Creator(s)

S. Todd Callahan, Monroe Carell Jr. Children's Hospital at Vanderbilt
Mark Wolff, The EMMES Corporation
Heather R. Hill, The EMMES Corporation
Kathryn M. Edwards, Vanderbilt University Medical Center
Wendy Keitel, Baylor College of Medicine
Robert Atmar, Baylor College of Medicine
Shital Patel, Baylor College of Medicine
Hana El Sahly, Baylor College of Medicine
Flor Munoz, Baylor College of Medicine
W. Paul Glezen, Baylor College of Medicine
Rebecca Brady, Cincinnati Children's Hospital Medical Center
Robert Frenck, Cincinnati Children's Hospital Medical Center
David Bernstein, Cincinnati Children's Hospital Medical Center
Christopher Harrison, Children's Mercy Hospitals and Clinics
Mary Anne Jackson, Children's Mercy Hospitals and Clinics
Douglas Swanson, Children's Mercy Hospitals and Clinics
Jason Newland, Children's Mercy Hospitals and Clinics
Angela Myers, Children's Mercy Hospitals and Clinics
Robyn A. Livingston, Children's Mercy Hospitals and Clinics
Emmanuel Walter, Duke University
Rowena Dolor, Duke University
Kenneth Schmader, Duke University
Mark J. Mulligan, Emory University
Srilatha Edupuganti, Emory University
Nadine Rouphael, Emory University
Jennifer Whitaker, Emory University
Paul Spearman, Emory University
Harry Keyserling, Emory University
Andi Shane, Emory University
Allison Ross Eckard, Emory University
Lisa A. Jackson, Group Health Research Institute
Sharon E. Frey, St. Louis University
Robert B. Belshe, St. Louis University

Document Type

Article

Publication Date

10-15-2014

Identifier

DOI: 10.1093/infdis/jiu245; PMCID: PMC4271072

Abstract

© The Author 2014. Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

Journal Title

Journal of Infectious Diseases

Volume

210

Issue

8

First Page

1270

Last Page

1274

Keywords

Body mass index; Immune response; Influenza vaccine; Obesity

Comments

Grant support

• HHSN272200800001O/AI/NIAID NIH HHS/United States
• HHSN272200800001C/AI/NIAID NIH HHS/United States
• HHSN272200800002C/AI/NIAID NIH HHS/United States
• HHSN272200800002C/PHS HHS/United States
• HHSN272200800013C/AI/NIAID NIH HHS/United States

• HHSN272200800004C/PHS HHS/United States
• HHSN272200800001I/AI/NIAID NIH HHS/United States
• HHSN27220080000C/PHS HHS/United States
• HHSN272200800004C/AI/NIAID NIH HHS/United States
• HHSN272200800001G/AI/NIAID NIH HHS/United States
• HHSN272200800001C/PHS HHS/United States
• HHSN272200800013C/PHS HHS/United States

Recommended Citation

Callahan, S. T., Wolff, M., Hill, H. R., Edwards, K. M., Keitel, W., Atmar, R., Patel, S., El Sahly, H., Munoz, F., Glezen, W. P., Brady, R., Frenck, R., Bernstein, D., Harrison, C., Jackson, M., Swanson, D., Newland, J., Myers, A., Livingston, R. A., Walter, E., Dolor, R., Schmader, K., Mulligan, M. J., Edupuganti, S., Rouphael, N., Whitaker, J., Spearman, P., Keyserling, H., Shane, A., Eckard, A., Jackson, L. A., Frey, S. E., Belshe, R. B. Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults Journal of Infectious Diseases 210, 1270-1274 (2014).