Regulatory role of NF-κB in growth plate chondrogenesis and its functional interaction with Growth Hormone.
Document Type
Article
Publication Date
8-20-2020
Identifier
DOI: 10.1016/j.mce.2020.110916
Abstract
Nuclear Factor kappa B (NF-kB) is a family of transcription factors that participates in the regulation of cell proliferation, migration, and apoptosis. Impaired NF-kB activity appears to be involved in the pathophysiology of inflammatory states, autoimmune diseases, and cancer. Genetic manipulation in mice leading to impaired NF-kB function is associated with abnormal limb development and delayed bone growth. We have previously shown in rodent cultured chondrocytes and cultured metatarsal bones that NF-kB promotes longitudinal bone growth and growth plate chondrocyte function. These NF-kB growth-promoting effects appear to be facilitated by Growth Hormone (GH) and Insulin-like Growth factor-1 (IGF-1). These stimulatory effects of GH and IGF-1 on NF-kB activity are supported by observational evidence in humans; a number of individuals carrying mutations that alter NF-kB function exhibit growth failure and GH insensitivity.
Journal Title
Molecular and cellular endocrinology
Volume
514
First Page
110916
Last Page
110916
PubMed ID
32569858
Recommended Citation
De Luca F. Regulatory role of NF-κB in growth plate chondrogenesis and its functional interaction with Growth Hormone. Mol Cell Endocrinol. 2020;514:110916. doi:10.1016/j.mce.2020.110916
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