Overcoming resistance to immunotherapy by teaching old drugs new tricks.

Creator(s)

John M. Perry, Children's Mercy HospitalFollow
Linheng Li

Document Type

Article

Publication Date

8-12-2020

Identifier

DOI: 10.1080/23723556.2020.1801088

Abstract

Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses of doxorubicin can target CSCs by restoring anticancer immunity.

Journal Title

Mol Cell Oncol

Volume

7

Issue

5

First Page

1801088

Last Page

1801088

Keywords

Akt; Cancer stem cells; Wnt; chemoresistance; immune checkpoints; immune escape; immune privilege; immunosurveillance; β-catenin

Recommended Citation

Perry JM, Li L. Overcoming resistance to immunotherapy by teaching old drugs new tricks. Mol Cell Oncol. 2020;7(5):1801088. Published 2020 Aug 12. doi:10.1080/23723556.2020.1801088