The Transatlantic HbA1c gap: differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Creator(s)

J M Hermann
K M Miller
S E Hofer
Mark A. Clements, Children's Mercy HospitalFollow
W Karges
N C Foster
E Fröhlich-Reiterer
M R Rickels
J Rosenbauer
D J DeSalvo
R W Holl
D M Maahs
T1D Exchange Clinic Network and the DPV initiative

Document Type

Article

Publication Date

5-2020

Identifier

DOI: 10.1111/dme.14148

Abstract

Aim: To compare HbA1c levels across the lifespan in people with type 1 diabetes in the USA with those in Germany/Austria, and to examine potential differences in HbA1c levels between sexes, insulin delivery methods and minority status.

Methods: Data were extracted from the US T1D Exchange Registry (n=18 381 participants from 73 sites) and from the German/Austrian Prospective Diabetes Follow-up Registry, the DPV (n=32 643 participants from 362 sites). Mean HbA1c was calculated for each year of age for individuals aged ≤25 years, and at 2-year age intervals for individuals aged >25 years. Curves for mean HbA1c by age were estimated using locally weighted scatterplot smoothing. HbA1c differences between registries, sexes, insulin delivery methods, and minority status were assessed by age group using multiple linear regression.

Results: In both registries, mean HbA1c increased by ~11 mmol/mol (1.0%) between the ages of 9 and 18 years, although at quite different absolute levels: from 66 mmol/mol (8.2%) to 77 mmol/mol (9.2%) in the T1D Exchange Registry, and from 56 mmol/mol (7.3%) to 66 mmol/mol (8.2%) in the DPV. Sex differences were observed in the DPV only. In the T1D Exchange Registry, injection users had higher mean HbA1c than pump users across the lifespan, whereas in the DPV higher HbA1c levels in injection users were observed in the age groups 6 to <12 >years, 12 to <18 >years, and 30 to(P < 0.001). Minority status was significantly associated with higher HbA1c in most age groups in both registries.

Conclusions: Significant differences in HbA1c were noted between the USA and Germany/Austria, with disparities more pronounced in early childhood through to young adulthood. Further studies should identify causes for these disparities.

RESULTS: In both registries, mean HbA

CONCLUSIONS: Significant differences in HbA

Journal Title

Diabetic medicine : a journal of the British Diabetic Association

Volume

37

Issue

5

First Page

848

Last Page

855

Comments

Grant support

• German Center for Diabetes Research (DZD)
• Leona M. and Harry B. Helmsley Charitable Trust
• German Diabetes Association (DDG)
• European Foundation for the study of Diabetes (EFSD)
• EU-IMI2 consortium INNODIA

Recommended Citation

Hermann JM, Miller KM, Hofer SE, et al. The Transatlantic HbA1c gap: differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry. Diabet Med. 2020;37(5):848-855. doi:10.1111/dme.14148