A pilot study to improve adherence among MS patients who discontinue treatment against medical advice.
Document Type
Article
Publication Date
4-1-2016
Identifier
DOI: 10.1007/s10865-015-9694-6
Abstract
Between 30 and 50% of MS patients may prematurely discontinue disease modifying therapies. Little research has examined how to best talk with patients who have discontinued treatment against medical advice. The aim of this pilot study was to determine whether telephone counseling increases disease modifying therapy (DMT) re-initiation among nonadherent patients with multiple sclerosis (MS). Participants were eligible if they had relapsing-remitting disease, had stopped taking a DMT, and had no plan to re-initiate treatment despite a provider recommendation. Following a baseline assessment, 81 patients were randomly assigned to either five 20 min, weekly sessions of Motivational Interviewing/Cognitive Behavioral Therapy (MI-CBT) or Treatment as Usual (TAU) with brief education. At 10 weeks, patients initially assigned to TAU switched over to MI-CBT. Compared to patients in the TAU group, patients undergoing MI-CBT were significantly more likely to indicate they were re-initiating DMT (41.7 vs. 14.3%). These significant results were replicated among patients crossing over from TAU to MI-CBT. Treatment satisfaction was high, with 97% of participants reporting that they would recommend MI-CBT to other patients with MS. Results of this pilot study provide initial support for the use of MI-CBT among MS patients who have discontinued treatment against medical advice.Clinicaltrials.gov: NCT01925690.
Journal Title
Journal of behavioral medicine
Volume
39
Issue
2
First Page
276
Last Page
287
MeSH Keywords
Adult; Antirheumatic Agents; Cognitive Therapy; Combined Modality Therapy; Counseling; Female; Humans; Male; Middle Aged; Motivational Interviewing; Multiple Sclerosis, Relapsing-Remitting; Patient Compliance; Patient Satisfaction; Pilot Projects; Telephone; Treatment Refusal
Keywords
Multiple Sclerosis; Patient Compliance
Recommended Citation
Bruce J, Bruce A, Lynch S, et al. A pilot study to improve adherence among MS patients who discontinue treatment against medical advice. J Behav Med. 2016;39(2):276-287. doi:10.1007/s10865-015-9694-6
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