Document Type
Article
Publication Date
6-2019
Identifier
DOI: 10.1124/dmd.119.086363; PMCID: PMC6505379
Abstract
The liver is the predominant organ of metabolism for many endogenous and foreign chemicals. Cytosolic sulfotransferases (SULTs) catalyze the sulfonation of drugs and other xenobiotics, as well as hormones, neurotransmitters, and sterols, with consequences that include enhanced drug elimination, hormone inactivation, and procarcinogen bioactivation. SULTs are classified into six gene families, but only SULT1 and SULT2 enzymes are expressed in human liver. We characterized the developmental expression patterns of SULT1 and SULT2 mRNAs and proteins in human liver samples using reverse transcription quantitative polymerase chain reaction (RT-qPCR), RNA sequencing, and targeted quantitative proteomics. Using a set of prenatal, infant, and adult liver specimens, RT-qPCR analysis demonstrated that
Journal Title
Drug metabolism and disposition: the biological fate of chemicals
Volume
47
Issue
6
First Page
592
Last Page
600
MeSH Keywords
Adolescent; Adult; Cytosol; Female; Humans; Infant; Infant, Newborn; Liver; Male; Middle Aged; RNA, Messenger; Sulfotransferases; Young Adult
Keywords
Adolescent; Adult; Cytosol; Female; Humans; Infant; Infant, Newborn; Liver; Male; Middle Aged; RNA, Messenger; Sulfotransferases; Young Adult
Recommended Citation
Dubaisi S, Caruso JA, Gaedigk R, et al. Developmental Expression of the Cytosolic Sulfotransferases in Human Liver. Drug Metab Dispos. 2019;47(6):592-600. doi:10.1124/dmd.119.086363
Comments
Grant support
U.S. Government work not protected by U.S. copyright
Publisher's Link: https://dmd.aspetjournals.org/content/47/6/592