Outcomes in omphalocele correlate with size of defect.
Document Type
Article
Publication Date
8-2019
Identifier
DOI: 10.1016/j.jpedsurg.2018.10.047
Abstract
BACKGROUND: Omphaloceles can be some of the more challenging cases managed by pediatric surgeons. Single center studies have not been meaningful in delineating outcomes due to the length of time required to accumulate a large enough series with historical changes in management negating the results. The purpose of this study was to evaluate factors impacting the morbidity and mortality of neonates with omphaloceles.
METHODS: A multicenter, retrospective observational study was performed for live born neonates with omphalocele between 2005 and 2013 at nine centers in the United States. Maternal and neonatal data were collected for each case. In-hospital management and outcomes were also reported and compared between neonates with small and large omphaloceles.
RESULTS: Two hundred seventy-four neonates with omphalocele were identified. The majority were delivered by cesarean section with a median gestational age of 37 weeks. Overall survival to hospital discharge was 81%. The presence of an associated anomaly was common, with cardiac abnormalities being the most frequent. Large omphaloceles had a significantly longer hospital and ICU length of stay, time on ventilator, number of tracheostomies, time on total parenteral nutrition, and time to full feeds, compared to small omphaloceles. Birth weight and defect size were independent predictors of survival.
CONCLUSION: This is the largest contemporary study of neonates with omphalocele. Increased defect size is an independent predictor of neonatal morbidity and mortality.
LEVEL OF EVIDENCE: Level II.
Journal Title
Journal of pediatric surgery
Volume
54
Issue
8
First Page
1546
Last Page
1550
MeSH Keywords
Birth Weight; Hernia, Umbilical; Humans; Infant, Newborn; Infant, Newborn, Diseases; Retrospective Studies
Keywords
Abdominal wall defect; Defect size; Length of stay; Neonates; Survival; Treatment
Recommended Citation
Raymond SL, Downard CD, St Peter SD, et al. Outcomes in omphalocele correlate with size of defect. J Pediatr Surg. 2019;54(8):1546-1550. doi:10.1016/j.jpedsurg.2018.10.047
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