PharmVar GeneFocus: CYP2C19.

Creator(s)

Mariana R. Botton
Michelle Whirl-Carrillo
Andria L. Del Tredici
Katrin Sangkuhl
Larisa H. Cavallari
José A G Agúndez
Jorge Duconge
Ming Ta Michael Lee
Erica L. Woodahl
Karla Claudio-Campos
Ann K. Daly
Teri E. Klein
Victoria M. Pratt
Stuart A. Scott
Andrea Gaedigk, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

2-2021

Identifier

DOI: 10.1002/cpt.1973

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Journal Title

Clinical pharmacology and therapeutics

Volume

109

Issue

2

First Page

352

Last Page

366

Comments

Grant support

• U24 HG010615/HG/NHGRI NIH HHS/United States
• U54 MD007600/MD/NIMHD NIH HHS/United States
• U54 MD007600-33/NIH/NIMHD
• R24 GM123930/GM/NIGMS NIH HHS/United States
• R24 GM123930/NH/NIH HHS/United States

• U01 HG010245/HG/NHGRI NIH HHS/United States
• R24 GM123930/NH/NIH HHS/United States
• R24 GM123930/GM/NIGMS NIH HHS/United States
• U24 HG010615/HG/NHGRI NIH HHS/United States
• U01 HG010245/HG/NHGRI NIH HHS/United States

Recommended Citation

Botton MR, Whirl-Carrillo M, Del Tredici AL, et al. PharmVar GeneFocus: CYP2C19. Clin Pharmacol Ther. 2021;109(2):352-366. doi:10.1002/cpt.1973