Bivalirudin and thrombolytic therapy: a novel successful treatment of severe aortic arch thrombosis in a term neonate.

Document Type

Article

Publication Date

1-18-2021

Identifier

DOI: 10.1136/bcr-2020-239535

Abstract

An early-term infant with uncomplicated perinatal history was found to have a large thrombus in the aortic arch after he failed regular newborn critical congenital heart defect screen. He responded well to bivalirudin thrombolytic and tissue-plasminogen activator (tPA) combination therapy, with a significant resolution of the thrombus. The infant tolerated hospital admission well with no significant complications. He was discharged home on daily aspirin at 2 weeks of life. To our knowledge, the combination therapy approach with bivalirudin and tPA is the first one reported in the literature in the neonatal age group.

Journal Title

BMJ Case Rep

Volume

14

Issue

1

Keywords

cardiovascular system; haematology (drugs and medicines); neonatal intensive care; paediatrics (drugs and medicines); routine care of the full-time infant

Link to Full Text
Library Record

Share

COinS