Airway Anomalies in Patients With 22q11.2 Deletion Syndrome: A 5-Year Review.

Document Type

Article

Publication Date

6-2018

Identifier

DOI: 10.1177/0003489418771711

Abstract

OBJECTIVES: To characterize the frequency of airway anomalies in patients with 22q11.2 deletion syndrome (22q11DS).

METHODS: Retrospective review of patients with 22q11DS who had undergone microlaryngoscopy/bronchoscopy (MLB) for aerodigestive symptoms at a tertiary care children's hospital from 2011 to 2016.

RESULTS: Thirty patients underwent an MLB due to the following indications: aspiration (11), stridor (10), chronic respiratory failure due to ventilator dependence (8), and difficult intubation (1). Median age at MLB was 6.5 months (range, 0.25-32 months). Forty airway anomalies were identified in 20 (66%) patients. Laryngomalacia (10), tracheomalacia (8), and bronchomalcia (8) were the most common intraoperative findings, followed by laryngeal cleft (5), anterior glottic web (5), subglottic stenosis (3), and subglottic cysts (1). Synchronous airway anomalies were common and identified in 11 (55%) of the patients who had identified anomalies on MLB. Nineteen of the 20 patients required operative intervention due to the anomalies identified.

CONCLUSIONS: Structural airway abnormalities are common in children with 22q11DS undergoing MLB, and synchronous anomalies can frequently exist. Providers caring for children with 22q11DS should be vigilant about airway evaluation when aerodigestive symptoms are present.

Journal Title

The Annals of otology, rhinology, and laryngology

Volume

127

Issue

6

First Page

384

Last Page

389

MeSH Keywords

Bronchoscopy; Child, Preschool; DiGeorge Syndrome; Female; Humans; Incidence; Infant; Infant, Newborn; Laryngoscopy; Male; Respiratory System Abnormalities; Retrospective Studies

Keywords

22q11.2 microdeletion syndrome; DiGeorge syndrome; laryngotracheal anomalies; pediatric otolaryngology; velocardiofacial syndrome

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