Title

Safety issues related to intravenous contrast agent use in magnetic resonance imaging.

Document Type

Article

Publication Date

5-2021

Identifier

DOI: 10.1007/s00247-020-04896-7

Abstract

Gadolinium-based contrast agents (GBCAs) have been used to improve image quality of MRI examinations for decades and have an excellent overall safety record. However, there are well-documented risks associated with GBCAs and our understanding and management of these risks continue to evolve. The purpose of this review is to discuss the safety of GBCAs used in MRI in adult and pediatric populations. We focus particular attention on acute adverse reactions, nephrogenic systemic fibrosis and gadolinium deposition. We also discuss the non-GBCA MRI contrast agent ferumoxytol, which is increasing in use and has its own risk profile. Finally, we identify special populations at higher risk of harm from GBCA administration.

Journal Title

Pediatric radiology

Volume

51

Issue

5

First Page

736

Last Page

747

Keywords

Adverse reaction; Children; Gadolinium deposition; Gadolinium-based contrast agent; Magnetic resonance imaging; Nephrogenic systemic fibrosis; Safety

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