Childhood Pulmonary Function, Exercise Capacity, and Exhaled Nitric Oxide Levels: Outcomes following Neonatal Treatment with Inhaled Nitric Oxide to Prevent Bronchopulmonary Dysplasia.

Document Type

Article

Publication Date

3-2019

Identifier

DOI: 10.1055/s-0038-1668556

Abstract

OBJECTIVE: The goal was to determine if inhaled nitric oxide (iNO) for 3 weeks during neonatal care of high-risk preterm infants was associated with improved pulmonary function and exercise capacity or altered exhaled nitric oxide (FeNO) levels in later childhood.

STUDY DESIGN: Thirty-four very preterm children previously enrolled in a randomized, neonatal trial of iNO to prevent chronic lung disease, were assessed in follow-up at 7 to 9 years of age, including pulmonary function testing (PFT), exercise testing, and measurement of FeNO.

RESULTS: There were no differences in PFTs or exercise capacity between iNO treated and controls. FeNO levels showed large interpatient variability but tended to be lower in the iNO treated.

CONCLUSION: Findings indicate no overall differences in pulmonary function or exercise capacity for children who had neonatal iNO treatment compared with placebo.

Journal Title

American journal of perinatology

Volume

36

Issue

4

First Page

360

Last Page

365

MeSH Keywords

Administration, Inhalation; Bronchodilator Agents; Bronchopulmonary Dysplasia; Child; Exercise Tolerance; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Lung; Male; Nitric Oxide; Respiratory Function Tests; Respiratory Insufficiency

Keywords

Administration, Inhalation; Bronchodilator Agents; Bronchopulmonary Dysplasia; Child; Exercise Tolerance; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Lung; Male; Nitric Oxide; Respiratory Function Tests; Respiratory Insufficiency

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