Gene expression in pediatric heart disease with emphasis on conotruncal defects.

Creator(s)

Douglas C. Bittel, Children's Mercy HospitalFollow
Nataliya Kibiryeva, Children's Mercy HospitalFollow
James E. O'Brien, Children's Mercy HospitalFollow
Gary K. Lofland, Children's Mercy Hospital
Merlin G. Butler, Children's Mercy Hospital

Document Type

Article

Publication Date

7-2005

Identifier

DOI: 10.1016/j.ppedcard.2005.04.004; PMCID: PMC5436709

Abstract

Developmental abnormalities of the heart are the underlying cause of many congenital heart malformations. The embryological development of the integrated cardiovascular tissue is the result of multiple tissue and cell-to-cell interactions involving temporal and spatial events under genetic control. Recent technological advances, like microarray analysis of gene expression, are providing new tools to aid in deciphering the complex networks of gene expression that regulate cardiac development. Here, we review our current understanding of the genetics of congenital heart disorders with emphasis on gene expression studies and report preliminary data from infants with conotruncal defects. We report our microarray analysis showing over- and underexpression of individual genes and gene network interactions from dysplastic pulmonic tissue from two infants with tetralogy of Fallot compared with normal pulmonic tissue from an unaffected control infant.

Journal Title

Progress in pediatric cardiology

Volume

20

Issue

2

First Page

127

Last Page

141

Keywords

Cardiac development; Congenital heart defects; Conotruncal defects; Gene expression; Microarray; Pediatric cardiology

Comments

Grant support

• U54 RR019478/RR/NCRR NIH HHS/United States

Recommended Citation

Bittel, D. C., Kibiryeva, N., O'Brien, J. E., Lofland, G. K., Butler, M. G. Gene expression in pediatric heart disease with emphasis on conotruncal defects. Progress in pediatric cardiology 20, 127-141 (2005).