T-lymphoblastic leukemia/lymphoma with interfollicular growth pattern and Castleman-like morphologic features

Creator(s)

Weijie Li, Children's Mercy HospitalFollow
Alexander Kats, Children's Mercy HospitalFollow
Linda D. Cooley, Children's Mercy HospitalFollow
Midhat Farooqi, Children's Mercy HospitalFollow
Keith August, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

3-12-2021

Identifier

DOI: 10.1007/s12308-021-00446-8

Abstract

Indolent T-lymphoblastic proliferation (iT-LBP) is a recently recognized benign pathologic condition commonly associated with Castleman disease. The lymph node of this condition shows preserved lymphoid architecture with proliferation of nonclonal T-lymphoblasts in the interfollicular area. iT-LBP is a rare condition and a diagnosis of exclusion. As a rule, it requires sophisticated techniques to exclude T-lymphoblastic leukemia/lymphoma (T-LBL/L). We present an unusual T-LBL/L in a lymph node mimicking iT-LBP. The case showed preserved nodal architecture, morphologic features of hyaline vascular Castleman disease, proliferation of T-lymphoblasts in the interfollicular area, and no clonal T-cell receptor gene rearrangement. The follow-up lymph node specimen excised 6 months later showed full-blown lymphoblastic lymphoma with an abnormal karyotype, near-early-T-precursor phenotype, partial CD19 expression, and SETD2 mutation.

Journal Title

Journal of Hematopathology

Volume

14

First Page

163

Last Page

169

Keywords

T-lymphoblastic leukemia/ lymphoma; Hyaline vascular Castleman disease; Indolent T-lymphoblastic proliferation

Recommended Citation

Li, W., Kats, A., Cooley, L.D. et al. T-lymphoblastic leukemia/lymphoma with interfollicular growth pattern and Castleman-like morphologic features. J Hematopathol 14, 163–169 (2021). https://doi.org/10.1007/s12308-021-00446-8