The role of carnitine in maintenance dialysis therapy.
Document Type
Article
Publication Date
8-2021
Identifier
DOI: 10.1007/s00467-021-05101-z
Abstract
Carnitine metabolism and homeostasis is significantly altered in patients receiving maintenance dialysis. Current literature in the adult and pediatric dialysis populations suggest a high prevalence of carnitine deficiency, which may lead to erythropoietin-resistant anemia, cardiomyopathy, and muscle weakness. However, the results of pediatric dialysis studies are limited and have not provided the evidence necessary to support strong recommendations or guidelines pertaining to carnitine management. The characteristics and function of carnitine, the definition and consequences of deficiency, a brief overview of recent adult studies, and current studies on carnitine supplementation in pediatric hemodialysis (HD) and peritoneal dialysis (PD) populations are discussed in this review.
Journal Title
Pediatric nephrology (Berlin, Germany)
Volume
36
Issue
8
First Page
2545
Last Page
2551
Keywords
Anemia; Carnitine; Deficiency; Hemodialysis; Kidney replacement therapy; Peritoneal dialysis; Supplementation
Recommended Citation
Morgans HA, Chadha V, Warady BA. The role of carnitine in maintenance dialysis therapy. Pediatr Nephrol. 2021;36(8):2545-2551. doi:10.1007/s00467-021-05101-z