Document Type

Article

Publication Date

1-1-2016

Identifier

PMCID: PMC5083068 DOI: 10.1016/j.jpedsurg.2015.10.028

Abstract

Purpose: The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD).

Methods: The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using random effects mixed modeling, we evaluated the association of operative type with change in hemoglobin, reticulocyte counts, and bilirubin. We also compared laparoscopic to open splenectomy.

Results: The analysis included 130 children, with 62.3% (n=81) undergoing TS. For children with HS, all hematologic measures improved after TS, including a 4.1g/dl increase in hemoglobin. Hematologic parameters also improved after PS, although the response was less robust (hemoglobin increase 2.4 g/dl, p

Conclusion: Children with HS have an excellent hematologic response after TS or PS, although the hematologic response is more robust following TS. Children with SCD have smaller changes in their hematologic parameters. These data offer guidance to families and clinicians considering TS or PS.

Journal Title

Journal of pediatric surgery

Volume

51

Issue

1

First Page

122

Last Page

127

MeSH Keywords

Adolescent; Anemia, Sickle Cell; Bilirubin; Child; Female; Hemoglobins; Humans; Laparoscopy; Male; Registries; Reticulocyte Count; Spherocytosis, Hereditary; Splenectomy

Keywords

Congenital hemolytic anemia; Hematologic outcomes; Splenectomy; Surgical technique; Sickle Cell

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