Towards better understanding of giant cell granulomas of the oral cavity.
Giant cell granulomas are enigmatic lesions of the oral cavity characterised by a peculiar combined proliferation of mononuclear and multinucleated giant cells in a mesenchymal stromal background. Central and peripheral giant cell granulomas may have similar pathogenesis and histology but differ in their location and biological behaviour. It is important to differentiate them from other giant cell lesions that can occur in the oral cavity, such as giant cell tumour of the bone, aneurysmal bone cyst, brown tumour of hyperparathyroidism, and giant cell lesions of Ramon syndrome, Noonan syndrome, neurofibromatosis and Jaffe-Campanacci syndrome. A recent insight into their molecular genetics and pathogenesis, with identification of KRAS, FGFR1 and TRPV4 mutations, allows for better diagnostic differentiation and opens the door to the use of pathway inhibitors in the treatment of recurrent or dysmorphic lesions. In this review, we provide an updated summary of the clinical and pathological features of oral cavity giant cell granulomas that help with their precise diagnosis and management.
Journal of clinical pathology
Adolescent; Adult; Aged; Biopsy; Cell Proliferation; Child; Child, Preschool; Diagnosis, Differential; Female; Genetic Predisposition to Disease; Giant Cells; Granuloma, Giant Cell; Humans; Immunophenotyping; Male; Middle Aged; Mouth; Mouth Diseases; Mutation; Phenotype; Predictive Value of Tests; Young Adult
bone neoplasms; granuloma; oral; pathology
Ahmed A, Naidu A. Towards better understanding of giant cell granulomas of the oral cavity. J Clin Pathol. 2021;74(8):483-490. doi:10.1136/jclinpath-2020-206858