Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology.

Document Type

Article

Publication Date

1-1-2016

Identifier

DOI: 10.1007/978-1-4939-3252-8_1

Abstract

Mass spectrometry (MS) has been used in research and specialized clinical laboratories for decades as a very powerful technology to identify and quantify compounds. In recent years, application of MS in routine clinical laboratories has increased significantly. This is mainly due to the ability of MS to provide very specific identification, high sensitivity, and simultaneous analysis of multiple analytes (>100). The coupling of tandem mass spectrometry with gas chromatography (GC) or liquid chromatography (LC) has enabled the rapid expansion of this technology. While applications of MS are used in many clinical areas, therapeutic drug monitoring, drugs of abuse, and clinical toxicology are still the primary focuses of the field. It is not uncommon to see mass spectrometry being used in routine clinical practices for those applications.

Journal Title

Methods in molecular biology (Clifton, N.J.)

Volume

1383

First Page

1

Last Page

10

MeSH Keywords

Chromatography, Liquid; Drug Monitoring; Humans; Substance Abuse Detection; Tandem Mass Spectrometry; Toxicology; Validation Studies as Topic

Keywords

Clinical laboratory; Drugs; Gas chromatography; Immunoassays; Liquid chromatography; Mass spectrometry; Tandem mass spectrometry; Therapeutic drug monitoring; Time-of-flight; Toxicology

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