Document Type

Article

Publication Date

7-2021

Identifier

DOI: 10.1016/j.epsc.2021.101894

Abstract

Fibrous hamartoma of infancy (FHI) is a rare, benign lesion characterized as a tumor of myofibroblastic origin that has characteristic features of triphasic histology. FHI was first described in 1956 by Reye and formally named by Enzinger in 1965. The lesion is defined as a hamartoma due to the histologic presentation of disorganized mesenchymal, fibrous, and adipose tissue with absence of mitotic figures; this combination of derived tissue without evidence of anaplasia is diagnostic for FHI. These lesions typically arise as a single, solitary mass, are most commonly located on the extremities, trunk, sacrum, or scrotum and are typically 0.5 to 9.0 centimeters in size. Only roughly 200 cases have been reported in the literature. The majority of cases occur in young children; 91% of cases arise within the first year of life. Males are more often affected in a ratio of 2.4:1. Roughly 20% of cases have been documented as congenital (3). Treatment is surgical excision, which is often curative; local recurrence is rare and incidence decreased by obtaining negative margins (8). We present a case of congenital FHI identified at birth.

Journal Title

Journal of Pediatric Surgery Case Reports

Volume

70

Keywords

Fibrous hamartoma of infancy; Infantile tumor; Hamartoma

Comments

This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.

Publisher's Link: https://www.sciencedirect.com/science/article/pii/S2213576621001159

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