Document Type
Article
Publication Date
8-11-2021
Identifier
DOI: 10.1155/2021/6567770; PMCID: PMC8373510
Abstract
Systemic juvenile idiopathic arthritis (sJIA) is a chronic, inflammatory disease of childhood, which is characterized by the combination of arthritis, serositis, daily, high-spiking fevers, and evanescent macular rash and can present with the life-threatening complication of macrophage activation syndrome (MAS). Children with Down syndrome (DS) have complex medical challenges related to abnormalities in their immune system, which can cause a broad spectrum of disease manifestations, which can occur atypically. Children with DS are at increased risk for arthritis and interstitial lung disease (ILD) associated with sJIA that has high mortality. This case report outlines an atypical presentation of sJIA in a 21-month-old male with DS in which fever was not part of the initial presentation of sJIA and then later developed MAS and ILD. Due to broad spectrum of disease and atypical presentation in children with DS, this case report was created to increase awareness of atypical presentations of rheumatic disease in children with DS.
Journal Title
Case Rep Pediatr
Volume
2021
First Page
6567770
Last Page
6567770
Recommended Citation
Worley E, Li W, Jones JT. Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome. Case Rep Pediatr. 2021;2021:6567770. Published 2021 Aug 11. doi:10.1155/2021/6567770
Comments
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher's Link: https://www.hindawi.com/journals/cripe/2021/6567770/