Mass Spectrometry in Clinical Laboratory: Applications in Biomolecular Analysis.

Document Type

Article

Publication Date

1-1-2016

Identifier

DOI: 10.1007/978-1-4939-3182-8_1

Abstract

Mass spectrometry (MS) is a technique that can identify analytes on the basis of mass-to-charge (m/z) ratio. Although this technique has been used in research and specialized clinical laboratories for decades, however, in recent years, MS has been increasingly used in routine clinical laboratories. MS, especially when coupled to gas chromatography or liquid chromatography, provides very specific and often sensitive analysis of many analytes. Other advantages of MS include simultaneous analysis of multiple analytes (>100) and generally without need for specialized reagents. Commonly measured analytes by MS include drugs, hormones, and proteins.

Journal Title

Methods in molecular biology (Clifton, N.J.)

Volume

1378

First Page

1

Last Page

9

MeSH Keywords

Clinical Chemistry Tests; Drug Monitoring; Endocrinology; Humans; Mass Spectrometry; Metabolic Diseases

Keywords

Clinical laboratory; Endocrinology; Gas chromatography; Hormones and proteins; Liquid chromatography; Mass spectrometry; Newborn screening; Tandem mass spectrometry

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