Mass Spectrometry in Clinical Laboratory: Applications in Biomolecular Analysis.
Mass spectrometry (MS) is a technique that can identify analytes on the basis of mass-to-charge (m/z) ratio. Although this technique has been used in research and specialized clinical laboratories for decades, however, in recent years, MS has been increasingly used in routine clinical laboratories. MS, especially when coupled to gas chromatography or liquid chromatography, provides very specific and often sensitive analysis of many analytes. Other advantages of MS include simultaneous analysis of multiple analytes (>100) and generally without need for specialized reagents. Commonly measured analytes by MS include drugs, hormones, and proteins.
Methods in molecular biology (Clifton, N.J.)
Clinical Chemistry Tests; Drug Monitoring; Endocrinology; Humans; Mass Spectrometry; Metabolic Diseases
Clinical laboratory; Endocrinology; Gas chromatography; Hormones and proteins; Liquid chromatography; Mass spectrometry; Newborn screening; Tandem mass spectrometry
Garg, U., Zhang, Y. V. Mass Spectrometry in Clinical Laboratory: Applications in Biomolecular Analysis. Methods in molecular biology (Clifton, N.J.) 1378, 1-9 (2016).