Thoracoscopic versus open lobectomy in infants with congenital lung malformations: A multi-institutional propensity score analysis.
Document Type
Article
Publication Date
12-2021
Identifier
DOI: 10.1016/j.jpedsurg.2021.04.013
Abstract
Purpose: The impact of thoracoscopic surgery on outcomes in children with congenital lung malformations (CLM) remains controversial. The purpose of this study was to determine the effect of operative approach on perioperative outcomes in infants undergoing lobectomy for an asymptomatic CLM.
Methods: After IRB approval, a retrospective cohort study was conducted on 506 children with a CLM resected at one of eleven children's hospitals over a seven-year period. Infants undergoing elective lobectomy were identified, and covariates were balanced based on operative approach using propensity scores with full matching. Outcomes were analyzed based on intention to treat with weighted conditional regression.
Results: One hundred seventy-five infants met inclusion criteria. There were 67 (38.3%) open, 89 (50.9%) thoracoscopic, and 19 (10.9%) thoracoscopic-converted-to-open lobectomies. Thoracoscopic lobectomy was associated with significantly longer operative times (26 min, 95% CI 6-47 min, p = 0.012) but used less epidural anesthesia (OR 0.02, 95% CI 0.004-0.11, p<0.001) when compared to open lobectomy. There were no significant differences in intraoperative blood loss, postoperative complications, chest tube duration, or length of stay.
Conclusions: Thoracoscopy has become the most common operative approach for elective lobectomy in infants with asymptomatic CLMs. The non-inferiority of thoracoscopic lobectomy in postoperative outcomes supports its continued use as an alternative to open lobectomy.
Level of evidence: Treatment study, Level III.
Journal Title
Journal of pediatric surgery
Volume
56
Issue
12
First Page
2148
Last Page
2156
MeSH Keywords
Child; Humans; Infant; Length of Stay; Lung; Lung Neoplasms; Pneumonectomy; Propensity Score; Retrospective Studies; Thoracoscopy; Treatment Outcome
Keywords
Bronchopulmonary sequestration; Congenital lobar emphysema; Congenital lung malformations; Congenital pulmonary airway malformation; Propensity score; Thoracoscopy
Recommended Citation
Weller JH, Peter SDS, Fallat ME, et al. Thoracoscopic versus open lobectomy in infants with congenital lung malformations: A multi-institutional propensity score analysis. J Pediatr Surg. 2021;56(12):2148-2156. doi:10.1016/j.jpedsurg.2021.04.013
COinS
Comments
Grant support