Human Parechovirus 3: The Most Common Viral Cause of Meningoencephalitis in Young Infants.
Document Type
Article
Publication Date
9-2015
Identifier
DOI: 10.1016/j.idc.2015.05.005
Abstract
Human parechoviruses (HPeVs) were initially classified as echoviruses. HPeVs occur worldwide, comprising up to 17 genotypes. HPeV1 and HPeV3 are most common. Clinical disease varies somewhat among genotypes. HPeV1 causes mostly gastrointestinal infections. HPeV3's prominence is due to its causing sepsis syndromes and central nervous system (CNS) infections in young infants. Currently, HPeV3 is the most common single cause of aseptic meningitis/meningoencephalitis in infants less than 90 days old in North America, usually with biannual summer-fall seasonality. HPeV3 CNS infections usually lack cerebrospinal fluid pleocytosis. Mortality and sequelae are uncommon, usually accompanying initially severe or neurologically complicated acute illnesses.
Journal Title
Infectious disease clinics of North America
Volume
29
Issue
3
First Page
415
Last Page
428
MeSH Keywords
Genotype; Humans; Infant; Male; Meningoencephalitis; North America; Parechovirus; Picornaviridae Infections; Seasons
Keywords
Encephalitis; HPeV; Meningitis; Neonate; Seizure; White matter
Recommended Citation
Renaud C, Harrison CJ. Human Parechovirus 3: The Most Common Viral Cause of Meningoencephalitis in Young Infants. Infect Dis Clin North Am. 2015;29(3):415-428. doi:10.1016/j.idc.2015.05.005
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