Title

Hypercalcemia: a consultant's approach.

Document Type

Article

Publication Date

9-1-2018

Identifier

DOI: 10.1007/s00467-017-3788-z

Abstract

Due to their daily involvement in mineral metabolism, nephrologists are often asked to consult on children with hypercalcemia. This might become even more pertinent when the hypercalcemia is associated with acute kidney injury and/or hypercalciuria and renal calcifications. The best way to assess the severity of hypercalcemia is by measurement of plasma ionized calcium, and if not available by adjusting serum total calcium to albumin concentration. The differential diagnosis of the possible etiologies of the disturbance in the mineral homeostasis starts with the assessment of serum parathyroid hormone concentration, followed by that of vitamin D metabolites in search of both genetic and acquired etiologies. Several tools are available to acutely treat hypercalcemia with the current main components being fluids, loop diuretics, and antiresorptive agents. This review will address the pathophysiologic mechanisms, clinical manifestations, and treatment modalities involved in hypercalcemia.

Journal Title

Pediatric nephrology (Berlin, Germany)

Volume

33

Issue

9

First Page

1475

Last Page

1488

MeSH Keywords

Hypercalcemia; Diphosphonates; Acute Kidney Injury; Child

Keywords

Acute kidney injury; Bisphosphonates; Calcitriol; PTH-related peptide; Parathyroid hormone; Vitamin D; Children

Share

COinS