Adrenocortical Function in Children With Brain Tumors and Pediatric Hematopoietic Cell Transplantation Recipients.

Creator(s)

Koral Shah
Jennifer W. Boyd, Children's Mercy HospitalFollow
Julia Broussard, Children's Mercy HospitalFollow
Kevin Ginn, Children's Mercy HospitalFollow
Rukhsana Rahmetulla, Children's Mercy HospitalFollow
Kristy Hurst, Children's Mercy HospitalFollow
Rakesh K. Goyal, Children's Mercy Hospital

Document Type

Article

Publication Date

3-1-2022

Identifier

DOI: 10.1097/MPH.0000000000002220

Abstract

Adrenocortical insufficiency (AI) is a clinical condition defined by deficient production of glucocorticoids that can result in life-threatening complications. We examined the prevalence of AI in children with brain tumors and those undergoing hematopoietic cell transplantation. Adrenocorticotropic hormone stimulation (stim) testing was used for the assessment of adrenocortical function. On the basis of 155 stim tests in 117 patients, AI was diagnosed in 27.4% of patients with brain tumors and in 21% of hematopoietic cell transplantation recipients. A number of risk factors associated with AI were identified. Adrenocorticotropic hormone stim testing led to a definitive diagnosis of AI or recovery of adrenal function and unambiguous medical management.

Journal Title

Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology

Volume

44

Issue

2

First Page

469

Last Page

473

Recommended Citation

Shah K, Boyd JW, Broussard JR, et al. Adrenocortical Function in Children With Brain Tumors and Pediatric Hematopoietic Cell Transplantation Recipients. J Pediatr Hematol Oncol. 2022;44(2):e469-e473. doi:10.1097/MPH.0000000000002220