Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.

Creator(s)

Chelsea M. Hosey, Children's Mercy Hospital
Kelsee Halpin, Children's Mercy HospitalFollow
Valentina Shakhnovich, Children's Mercy HospitalFollow
Chengpeng Bi, Children's Mercy HospitalsFollow
Brooke Sweeney, Children's MercyFollow
Yun Yan, Children's Mercy HospitalFollow
J Steven Leeder, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

4-2022

Identifier

DOI: 10.1111/cts.13207; PMCID: PMC9010268

Abstract

An accurate understanding of the changes in height and weight of children with age is critical to the development of models predicting drug concentrations in children (i.e., physiologically-based pharmacokinetic models). However, curves describing the growth of a typical population of children may not accurately characterize growth of children with various conditions, such as obesity. Therefore, to develop height and weight versus age growth curves for youth who were diagnosed with type 2 diabetes, we extracted data from electronic medical records. Robust nonlinear models were parameterized to the equations describing height and weight versus age as defined by the Centers for Disease Control and Prevention (CDC). CDC z-scores were calculated using an internal program. The growth curves and z-scores were compared to CDC norms. Youth with type 2 diabetes were increasingly heavier than CDC norms from early childhood. Except for a period around puberty, youth with type 2 diabetes were, on average, shorter than CDC norms, resulting in shorter average adult height. Deviations in growth were apparent in youth who develop type 2 diabetes; such deviations may be expected for other conditions as well, and disease-specific growth curves should be considered during development of model-informed drug development for pediatric conditions.

Journal Title

Clin Transl Sci

Volume

15

Issue

4

First Page

912

Last Page

922

MeSH Keywords

Adolescent; Adult; Body Height; Body Mass Index; Body Weight; Child; Child Development; Child, Preschool; Diabetes Mellitus, Type 2; Humans; Obesity

Keywords

Body Height; Body Mass Index; Body Weight; Child Development; Diabetes Mellitus, Type 2; Obesity

Comments

Grant support

• P50 HD090258/HD/NICHD NIH HHS/United States
• P50HD090258/Children's Mercy Hospital

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Publisher's Link: https://ascpt.onlinelibrary.wiley.com/doi/10.1111/cts.13207

Recommended Citation

Hosey CM, Halpin K, Shakhnovich V, et al. Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models. Clin Transl Sci. 2022;15(4):912-922. doi:10.1111/cts.13207