Neurodevelopmental profiles of infants born <30 weeks gestation at 2 years of age.
Document Type
Article
Publication Date
5-2022
Identifier
DOI: 10.1038/s41390-021-01871-2; PMCID: PMC9177895
Abstract
BACKGROUND: Infants born(PMA) are at increased risk for neurodevelopmental impairment by age 2. Prior studies report rates of impairment for individual outcomes separately. Our objective was to describe neurodevelopmental profiles of children bornPMA, using cognitive, language, motor, and behavioral characteristics.
METHODS: We studied 587 children from a multi-center study of infants bornscores, Child Behavior Checklist syndrome scores, diagnosis of cerebral palsy (CP), and positive screen for autism spectrum disorder (ASD) risk. We used latent profile analysis (LPA) to group children into mutually exclusive profiles.
RESULTS: We found four discrete neurodevelopmental profiles indicating distinct combinations of developmental and behavioral outcomes. Two of the profiles included 72.7% of the sample with most having Bayley scores within the normal range. The other two profiles included the remaining 27.3% of the sample with most having Bayley scores outside of the normal range. Only one profile (11% of sample) was comprised of children with elevated behavioral problems.
CONCLUSION: Child-centered analysis techniques could facilitate the development of targeted intervention strategies and provide caregivers and practitioners with an integrative understanding of child behavior.
IMPACT: Most studies examining neurodevelopmental outcomes in very preterm children report rates of impairment for individual outcomes separately. Comprehensive, "child-centered" approaches that integrate across multiple domains can be used to identify subgroups of children who experience different types of neurodevelopmental impairments. We identified four discrete neurodevelopmental profiles indicating distinct combinations of developmental and behavioral outcomes in very preterm children at 24 months. "Child-centered" analysis techniques may provide clinically useful information and could facilitate the development of targeted intervention strategies for high-risk children.
Journal Title
Pediatric research
Volume
91
Issue
6
First Page
1579
Last Page
1586
MeSH Keywords
Autism Spectrum Disorder; Cerebral Palsy; Child; Child Development; Child, Preschool; Developmental Disabilities; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Neurodevelopmental Disorders; Pregnancy; Prospective Studies
Keywords
Autism Spectrum Disorder; Cerebral Palsy; Child; Child Development; Child, Preschool; Developmental Disabilities; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Neurodevelopmental Disorders; Pregnancy; Prospective Studies
Recommended Citation
Camerota M, McGowan EC, Hofheimer JA, et al. Neurodevelopmental profiles of infants born <30 weeks gestation at 2 years of age. Pediatr Res. 2022;91(6):1579-1586. doi:10.1038/s41390-021-01871-2
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