DOI: 10.1177/2050313X221118732; PMCID: PMC9393921
Presentation, management, and outcomes of COVID-19 infections among younger patients is an area of medicine with deficits in research, likely due to the lower incidence of severe COVID-19 disease among the younger population. Management can be challenging, and clinicians often guide their decision-making based on the ever-changing protocols that are tailored mostly to the elderly population. Even more underrepresented in COVID-19 research are patients with chromosomal abnormalities and trisomy syndromes, as they appear less frequently, but have risk of increased morbidity and mortality due to underlying medical conditions. We describe a case of severe COVID-19 infection in a young patient with mosaic trisomy 13 and pre-existing polycystic kidney disease, who developed severe acute hypoxic respiratory failure and acute chronic kidney injury. The patient was provided maximal pharmacological support and her clinical course helps to shape the understanding of COVID-19 infections in the setting of chromosomal abnormalities and complex medical history.
SAGE Open Med Case Rep
COVID-19; Patau syndrome; mosaic; polycystic kidney disease; trisomy 13
Ost NK, Minchew HM, Garcia A, Ganatra HA. COVID-19 in a mosaic trisomy 13 patient with polycystic kidney disease. SAGE Open Med Case Rep. 2022;10:2050313X221118732. Published 2022 Aug 17. doi:10.1177/2050313X221118732