Vaccination after SARS-CoV-2 infection increased antibody avidity against the Omicron variant compared to vaccination alone.

Creator(s)

Cas LeMaster, Children's Mercy HospitalFollow
Eric S. Geanes, Children's Mercy HospitalFollow
Elizabeth Fraley, Children's Mercy HospitalFollow
Rangaraj Selvarangan, Children's Mercy HospitalFollow
Todd Bradley, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

11-11-2022

Identifier

DOI: 10.1093/infdis/jiac247; PMCID: PMC9214134

Abstract

The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the Omicron variant after two doses of the Pfizer COVID-19 mRNA vaccine. Individuals recovered from infection before vaccination had higher antibody levels and avidity to the Omicron variant compared to individuals vaccinated without infection. This suggested that COVID-19 infection before vaccination elicited a higher magnitude and affinity antibody response to the Omicron variant, and repeated exposure through infection or vaccine may be required to improve immunity to emerging SARS-CoV-2 variants.

Journal Title

The Journal of infectious diseases

Volume

226

Issue

10

First Page

1712

Last Page

1716

Keywords

COVID-19; SARS-CoV-2; antibody response; vaccine

Comments

Grant support

• Children's Mercy Research Institute
• Children's Mercy Kansas City

Recommended Citation

LeMaster C, Geanes ES, Fraley ER, Selvarangan R, Bradley T. Vaccination After SARS-CoV-2 Infection Increased Antibody Avidity Against the Omicron Variant Compared to Vaccination Alone. J Infect Dis. 2022;226(10):1712-1716. doi:10.1093/infdis/jiac247