Title

Vaccination after SARS-CoV-2 infection increased antibody avidity against the Omicron variant compared to vaccination alone.

Document Type

Article

Publication Date

11-11-2022

Identifier

DOI: 10.1093/infdis/jiac247; PMCID: PMC9214134

Abstract

The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the Omicron variant after two doses of the Pfizer COVID-19 mRNA vaccine. Individuals recovered from infection before vaccination had higher antibody levels and avidity to the Omicron variant compared to individuals vaccinated without infection. This suggested that COVID-19 infection before vaccination elicited a higher magnitude and affinity antibody response to the Omicron variant, and repeated exposure through infection or vaccine may be required to improve immunity to emerging SARS-CoV-2 variants.

Journal Title

The Journal of infectious diseases

Volume

226

Issue

10

First Page

1712

Last Page

1716

Keywords

COVID-19; SARS-CoV-2; antibody response; vaccine

Library Record

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