Intravenous iron therapy in the pediatric sleep clinic: a single institution experience.

Document Type

Article

Publication Date

11-1-2022

Identifier

DOI: 10.5664/jcsm.10152

Abstract

STUDY OBJECTIVES: Initial reports of intravenous (IV) iron administration have been promising for children with restless legs syndrome, periodic limb movement disorder, and restless sleep disorder. The aim of the current study was to evaluate further the clinical response to IV iron supplementation in children seen in a pediatric sleep clinic.

METHODS: We performed a retrospective chart review of children cared for in a single pediatric sleep clinic who also underwent IV iron infusion. Pre and post IV data regarding their sleep symptoms and ferritin levels were abstracted.

RESULTS: Overall, 63 pediatric sleep patients underwent IV iron infusion, mostly with ferric carboxymaltose (n = 60), for restless legs syndrome (n = 30), periodic limb movement disorder (n = 22), and restless sleep disorder (n = 17). Of the 59 patients with clinical follow-up, 39 (73%) noted improvement in at least 1 symptom, and 14 (26%) did not notice improvement or noticed worsening symptoms. Of the 59 patients with preinfusion and postinfusion labs, the average ferritin level increased from 21.7 (13.3) to 147.9 (120.9) μg/L,

CONCLUSIONS: These data provide additional support for the efficacy and safety of IV iron for pediatric restless legs syndrome, periodic limb movement disorder, and restless sleep disorder recalcitrant to oral iron.

CITATION: Ingram DG, Al-Shawwa B, DelRosso LM, Sharma M. Intravenous iron therapy in the pediatric sleep clinic: a single institution experience.

Journal Title

J Clin Sleep Med

Volume

18

Issue

11

First Page

2545

Last Page

2551

MeSH Keywords

Humans; Child; Nocturnal Myoclonus Syndrome; Restless Legs Syndrome; Retrospective Studies; Ferritins; Iron; Sleep Wake Disorders; Sleep

Keywords

IV iron; pediatric; restless leg syndrome

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