Skin Toxicity Due to Mercaptopurine in Maintenance Therapy Among Children With Acute Lymphoblastic Leukemia.

Document Type

Article

Publication Date

5-1-2023

Identifier

DOI: 10.1097/MPH.0000000000002667

Abstract

Mercaptopurine is a crucial component in the treatment of acute lymphoblastic leukemia. It is associated with toxicities that can delay treatment. Mercaptopurine is metabolized into 6-thioguanine nucleotides and 6-methylomercaptopurine nucleotides (6MMPN). Accumulation of 6MMPN has previously been associated with hepatotoxicity, pancreatitis, and hypoglycemia. However, skin toxicity has rarely been reported. We report 5 cases of elevated 6MMPN levels associated with cutaneous manifestations.

Journal Title

Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology

Volume

45

Issue

4

First Page

514

Last Page

514

MeSH Keywords

Child; Humans; Mercaptopurine; Antimetabolites, Antineoplastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Diseases; Thioguanine

Keywords

Child; Humans; Mercaptopurine; Antimetabolites, Antineoplastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Diseases; Thioguanine

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