Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion.

Creator(s)

Erica Wee, Children's Mercy Kansas CityFollow
John Herriges, Children's Mercy HospitalFollow
Kavitha Dileepan, Children's Mercy HospitalFollow
Sarah Tsai, Children's Mercy HospitalFollow
Joseph Alaimo, Children's Mercy HospitalFollow
Emily Paprocki, Children's Mercy Kansas CityFollow

Document Type

Article

Publication Date

6-26-2023

Identifier

DOI: 10.1155/2023/8658540; PMCID: PMC10317580

Abstract

Hypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia is essential in providing appropriate treatment. Hyperinsulinism and growth hormone deficiency are known causes of hypoglycemia but are not commonly found together. We report a 4-month-old boy who presented with severe hypoglycemia and was found to have both hyperinsulinism and growth hormone deficiency. Treatment with both recombinant human growth hormone and diazoxide led to blood glucose normalization. Subsequently, he was found to have a genetic diagnosis of 20p11.22p11.21 deletion. 20p11 deletions have been associated with hypopituitarism, most commonly seen in growth hormone deficiency causing hypoglycemia. This case is one of a few to report hyperinsulinism as a manifestation of this deletion.

Journal Title

Case Rep Endocrinol

Volume

2023

First Page

8658540

Last Page

8658540

Comments

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher's Link: https://www.hindawi.com/journals/crie/2023/8658540/

Recommended Citation

Wee E, Herriges J, Dileepan K, Tsai SL, Alaimo JT, Paprocki E. Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion. Case Rep Endocrinol. 2023;2023:8658540. Published 2023 Jun 26. doi:10.1155/2023/8658540