Document Type

Article

Publication Date

7-8-2023

Identifier

DOI: 10.1038/s41598-023-37937-w; PMCID: PMC10329665

Abstract

The purpose of the current study was to assess the frequency of overactive bladder syndrome (OBS) symptoms and their relationship to gastrointestinal symptoms in youth with abdominal pain-associated disorders of gut-brain interaction (AP-DGBI). This is a retrospective study of 226 youth diagnosed with an AP-DGBI. As part of standard care, all patients completed a symptom questionnaire regarding gastrointestinal and non-gastrointestinal symptoms including increased urinary frequency, nighttime urination, and urinary urgency. Overall, 54% of patients reported at least one OBS symptom. Increased frequency of urination was reported by 19%, urinary urgency by 34%, and nighttime urination by 36%. Increased frequency of urination and urinary urgency were associated with a change in stool form, a change in stool frequency, and in those fulfilling criteria for IBS. Increased frequency of urination was reported more frequently in those reporting predominantly loose stools (33% vs. 12%). Urinary symptoms are common in youth with AP-DGBI. Increased urinary frequency and urinary urgency are specifically associated with IBS, with increased urinary frequency being primarily associated with diarrhea predominant IBS. Further studies are needed to determine the impact of OBS on AP-DGBI severity and quality of life, and whether they impact DGBI treatment.

Journal Title

Sci Rep

Volume

13

Issue

1

First Page

11042

Last Page

11042

MeSH Keywords

Humans; Adolescent; Urinary Bladder, Overactive; Irritable Bowel Syndrome; Retrospective Studies; Quality of Life; Abdominal Pain; Diarrhea; Urinary Bladder Diseases; Gastrointestinal Diseases; Urination Disorders; Brain

Keywords

Overactive Urinary Bladder; Irritable Bowel Syndrome; Retrospective Studies; Quality of Life; Abdominal Pain; Diarrhea; Urinary Bladder Diseases; Gastrointestinal Diseases; Urination Disorders; Brain

Comments

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Publisher's Link: https://www.nature.com/articles/s41598-023-37937-w

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