Document Type

Article

Publication Date

7-27-2023

Identifier

DOI: 10.1136/bmjopen-2022-066343

Abstract

INTRODUCTION: Portal vein obstruction (PVO) consists of anastomotic stenosis and thrombosis, which occurs due to a progression of the former. The aim of this large-scale international study is to assess the prevalence, current management practices and efficacy of treatment in patients with PVO.

METHODS AND ANALYSIS: The Portal vein Obstruction Revascularisation Therapy After Liver transplantation registry will facilitate an international, retrospective, multicentre, observational study, with 25 centres around the world already actively involved. Paediatric patients (agedyears) with a diagnosed PVO between 1 January 2001 and 1 January 2021 after liver transplantation will be eligible for inclusion. The primary endpoints are the prevalence of PVO, primary and secondary patency after PVO intervention and current management practices. Secondary endpoints are patient and graft survival, severe complications of PVO and technical success of revascularisation techniques.

ETHICS AND DISSEMINATION: Medical Ethics Review Board of the University Medical Center Groningen has approved the study (METc 2021/072). The results of this study will be disseminated via peer-reviewed publications and scientific presentations at national and international conferences.

TRIAL REGISTRATION NUMBER: Netherlands Trial Register (NL9261).

Journal Title

BMJ Open

Volume

13

Issue

7

First Page

066343

Last Page

066343

MeSH Keywords

Humans; Child; Liver Transplantation; Portal Vein; Retrospective Studies; Prevalence; Liver Diseases; Vascular Diseases; Registries; Observational Studies as Topic; Multicenter Studies as Topic

Keywords

Interventional radiology; Paediatric hepatology; Paediatric transplant surgery

Comments

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Publisher's Link: https://bmjopen.bmj.com/content/13/7/e066343.long

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