Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung.

Creator(s)

Heather Menden, Children's Mercy HospitalFollow
Sheng Xia, Children's Mercy HospitalFollow
Sherry M. Mabry, Children's Mercy HospitalFollow
Angels Navarro, Children's Mercy Hospital
Michael F. Nyp, Children's Mercy HospitalFollow
Venkatesh Sampath, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

12-1-2016

Identifier

PMCID: PMC5248953 DOI: 10.1165/rcmb.2016-0006OC

Abstract

In premature infants, sepsis is associated with alveolar simplification manifesting as bronchopulmonary dysplasia. The redox-dependent mechanisms underlying sepsis-induced inflammation and alveolar remodeling in the immature lung remain unclear. We developed a neonatal mouse model of sepsis-induced lung injury to investigate whether nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) regulates Toll-like receptor (TLR)-mediated inflammation and alveolar remodeling. Six-day-old NOX2

Journal Title

American journal of respiratory cell and molecular biology

Volume

55

Issue

6

First Page

767

Last Page

778

MeSH Keywords

Acute Disease; Animals; Biomarkers; Cytokines; Extracellular Matrix; Lipopolysaccharides; Membrane Glycoproteins; Mice; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Pneumonia; Pulmonary Alveoli; Sepsis; Toll-Like Receptors; Transcription Factor AP-1

Keywords

Toll-like receptor signaling; bronchopulmonary dysplasia; neonatal lung injury; nicotinamide adenine dinucleotide phosphate oxidase; sepsis

Recommended Citation

Menden HL, Xia S, Mabry SM, Navarro A, Nyp MF, Sampath V. Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung. Am J Respir Cell Mol Biol. 2016;55(6):767-778. doi:10.1165/rcmb.2016-0006OC