Document Type
Article
Publication Date
8-15-2023
Identifier
DOI: 10.1186/s13046-023-02786-y; PMCID: PMC10426107
Abstract
The advances in cancer research achieved in the last 50 years have been remarkable and have provided a deeper knowledge of this disease in many of its conceptual and biochemical aspects. From viewing a tumor as a 'simple' aggregate of mutant cells and focusing on detecting key cell changes leading to the tumorigenesis, the understanding of cancer has broadened to consider it as a complex organ interacting with its close and far surroundings through tumor and non-tumor cells, metabolic mechanisms, and immune processes. Metabolism and the immune system have been linked to tumorigenesis and malignancy progression along with cancer-specific genetic mutations. However, most technologies developed to overcome the barriers to earlier detection are focused solely on genetic information. The concept of cancer as a complex organ has led to research on other analytical techniques, with the quest of finding a more sensitive and cost-effective comprehensive approach. Furthermore, artificial intelligence has gained broader consensus in the oncology community as a powerful tool with the potential to revolutionize cancer diagnosis for physicians. We herein explore the relevance of the concept of cancer as a complex organ interacting with the bodily surroundings, and focus on promising emerging technologies seeking to diagnose cancer earlier, such as liquid biopsies. We highlight the importance of a comprehensive approach to encompass all the tumor and non-tumor derived information salient to earlier cancer detection.
Journal Title
Journal of experimental & clinical cancer research : CR
Volume
42
Issue
1
First Page
207
Last Page
207
MeSH Keywords
Humans; Artificial Intelligence; Neoplasms; Liquid Biopsy; Medical Oncology; Carcinogenesis; Biomarkers, Tumor
Keywords
Blood serum; Cancer detection; Diagnosis; Genetics; Immune system; Liquid biopsy; Metabolism; Pan-omics.; Spectroscopy; Tumorigenesis
Recommended Citation
Sala A, Cameron JM, Brennan PM, Crosbie EJ, Curran T, Gray E, Martin-Hirsch P, Palmer DS, Rehman IU, Rattray NJW, Baker MJ. Global serum profiling: an opportunity for earlier cancer detection. J Exp Clin Cancer Res. 2023 Aug 15;42(1):207. doi: 10.1186/s13046-023-02786-y. PMID: 37580713; PMCID: PMC10426107.
Comments
Grant support
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Publisher's Link: https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02786-y