Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative.

Creator(s)

Raina Paul
Matthew Niedner
Ruth Riggs
Troy Richardson
Heidi Gruhler DeSouza
Jeffery J. Auletta
Frances Balamuth
Deborah Campbell
Holly Depinet
Leslie Hueschen, Children's Mercy HospitalFollow
W Charles Huskins
Sarah B. Kandil
Gitte Larsen
Elizabeth H. Mack
Gregory P. Priebe
Lori E. Rutman
Melissa Schafer
Halden Scott
Pete Silver
Erika L. Stalets
Beth A. Wathen
Charles G. Macias
Richard J. Brilli
IPSO COLLABORATIVE INVESTIGATORS

Document Type

Article

Publication Date

8-1-2023

Identifier

DOI: 10.1542/peds.2022-059938

Abstract

OBJECTIVES: We sought to improve utilization of a sepsis care bundle and decrease 3- and 30- day sepsis-attributable mortality, as well as determine which care elements of a sepsis bundle are associated with improved outcomes.

METHODS: Children's Hospital Association formed a QI collaborative to Improve Pediatric Sepsis Outcomes (IPSO) (January 2017-March 2020 analyzed here). IPSO Suspected Sepsis (ISS) patients were those without organ dysfunction where the provider "intended to treat" sepsis. IPSO Critical Sepsis (ICS) patients approximated those with septic shock. Process (bundle adherence), outcome (mortality), and balancing measures were quantified over time using statistical process control. An original bundle (recognition method, fluid bolus < 20 min, antibiotics < 60 min) was retrospectively compared with varying bundle time-points, including a modified evidence-based care bundle, (recognition method, fluid bolus < 60 min, antibiotics < 180 min). We compared outcomes using Pearson χ-square and Kruskal Wallis tests and adjusted analysis.

RESULTS: Reported are 24 518 ISS and 12 821 ICS cases from 40 children's hospitals (January 2017-March 2020). Modified bundle compliance demonstrated special cause variation (40.1% to 45.8% in ISS; 52.3% to 57.4% in ICS). The ISS cohort's 30-day, sepsis-attributable mortality dropped from 1.4% to 0.9%, a 35.7% relative reduction over time (P < .001). In the ICS cohort, compliance with the original bundle was not associated with a decrease in 30-day sepsis-attributable mortality, whereas compliance with the modified bundle decreased mortality from 4.75% to 2.4% (P < .01).

CONCLUSIONS: Timely treatment of pediatric sepsis is associated with reduced mortality. A time-liberalized care bundle was associated with greater mortality reductions.

Journal Title

Pediatrics

Volume

152

Issue

2

Recommended Citation

Paul R, Niedner M, Riggs R, et al. Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Pediatrics. 2023;152(2):e2022059938. doi:10.1542/peds.2022-059938