Chronic Kidney Disease
Neonatal chronic kidney disease (CKD) is diagnosed when sustained derangements of glomerular filtration or tubular function occur with minimal to no resolution over time. As kidney development continues until 34 weeks gestation, neonatal intensive care unit graduates, especially those with a history of acute kidney injury (AKI), premature infants, and those with intrauterine growth retardation, are at risk for long-term CKD. Clinical sequelae of CKD include anemia, acidosis, electrolyte abnormality, growth restriction, renal osteodystrophy, fluid overload, hypertension, and uremia. Attention to these complications is critical to optimizing long-term outcomes. Long-term survival of neonates with end-stage kidney disease (ESKD) appears to be approaching that of older infants and young children, but they continue to have higher morbidity and mortality due to infectious and cardiovascular complications.
Avery's Diseases of the Newborn
Chronic kidney disease (CKD); renal kidney failure; dialysis; neonate; outcomes
Willig L, Warady B. Chronic kidney disease. Avery’s Diseases of the Newborn (11th Ed). Published online 2024:1139-1147. doi:10.1016/b978-0-323-82823-9.00078-7