Cholestasis is associated with a higher rate of complications in both medical and surgical necrotizing enterocolitis.
Document Type
Article
Publication Date
1-2024
Identifier
DOI: 10.1038/s41372-023-01787-1
Abstract
OBJECTIVE: To evaluate the relationship between cholestasis and outcomes in medical and surgical necrotizing enterocolitis (NEC).
STUDY DESIGN: A retrospective analysis of prospectively collected data from 1472 infants with NEC [455 medical (mNEC) and 1017 surgical (sNEC)] from the Children's Hospital Neonatal Database.
RESULTS: The prevalence of cholestasis was lower in mNEC versus sNEC (38.2% vs 70.1%, p < 0.001). In both groups, cholestasis was associated with lower birth gestational age [mNEC: OR 0.79 (95% CI 0.68-0.92); sNEC: OR 0.86 (95% CI 0.79-0.95)] and increased days of parenteral nutrition [mNEC: OR 1.08 (95% CI 1.04-1.13); sNEC: OR 1.01 (95% CI 1.01-1.02)]. For both groups, the highest direct bilirubin was associated with the composite outcome mortality or length of stay >75th percentile [mNEC: OR 1.21 (95% CI 1.06-1.38); sNEC: OR 1.06 (95% CI 1.03-1.09)].
CONCLUSION: Cholestasis with both medical NEC and surgical NEC is associated with adverse patient outcomes including increased mortality or extreme length of stay.
Journal Title
Journal of perinatology : official journal of the California Perinatal Association
Volume
44
Issue
1
First Page
100
Last Page
107
MeSH Keywords
Infant; Child; Infant, Newborn; Humans; Retrospective Studies; Enterocolitis, Necrotizing; Gestational Age; Parenteral Nutrition; Infant, Newborn, Diseases; Cholestasis
Keywords
Retrospective Studies; Necrotizing Enterocolitis; Gestational Age; Parenteral Nutrition; Newborn Diseases; Cholestasis
Recommended Citation
Nayak SP, Huff KA, Zaniletti I, et al. Cholestasis is associated with a higher rate of complications in both medical and surgical necrotizing enterocolitis. J Perinatol. 2024;44(1):100-107. doi:10.1038/s41372-023-01787-1
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