Ethical challenges in first-in-human trials of the artificial placenta and artificial womb: not all technologies are created equally, ethically.
Document Type
Article
Publication Date
11-2023
Identifier
DOI: 10.1038/s41372-023-01713-5
Abstract
Artificial placenta and artificial womb technologies to support extremely premature neonates are advancing toward clinical testing in humans. Currently, no recommendations exist comparing these approaches to guide study design and optimal enrollment eligibility adhering to principles of research ethics. In this paper, we will explore how scientific differences between the artificial placenta and artificial womb approaches create unique ethical challenges to designing first-in-human trials of safety and provide recommendations to guide ethical study design for initial human translation.
Journal Title
Journal of perinatology : official journal of the California Perinatal Association
Volume
43
Issue
11
First Page
1337
Last Page
1342
MeSH Keywords
Infant, Newborn; Pregnancy; Female; Humans; Placenta; Uterus; Research Design; Infant, Newborn, Diseases
Keywords
Pregnancy; Placenta; Uterus; Research Design; Newborn Diseases
Recommended Citation
Kukora SK, Mychaliska GB, Weiss EM. Ethical challenges in first-in-human trials of the artificial placenta and artificial womb: not all technologies are created equally, ethically. J Perinatol. 2023;43(11):1337-1342. doi:10.1038/s41372-023-01713-5
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