Bronchopulmonary dysplasia - associated pulmonary hypertension: An updated review.
Document Type
Article
Publication Date
10-2023
Identifier
DOI: 10.1016/j.semperi.2023.151817
Abstract
Bronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in infants and the commonest complication of prematurity. Advances in respiratory and overall neonatal care have increased the survival of extremely low gestational age newborns, leading to the continued high incidence of BPD. Pulmonary hypertension (PH) represents the severe form of the pulmonary vascular disease associated with BPD, and affects almost one-third of infants with moderate to severe BPD. PH responds suboptimally to pulmonary vasodilators and increases morbidity and mortality in BPD infants. An up-to-date knowledge of the pathogenesis, pathophysiology, diagnosis, treatment, and outcomes of BPD-PH can be helpful to develop meaningful and novel strategies to improve the outcomes of infants with this disorder. Therefore, our multidisciplinary team has attempted to thoroughly review and summarize the latest advances in BPD-PH in preventing and managing this morbid lung disorder of preterm infants.
Journal Title
Seminars in perinatology
Volume
47
Issue
6
First Page
151817
Last Page
151817
MeSH Keywords
Infant; Infant, Newborn; Humans; Bronchopulmonary Dysplasia; Infant, Premature; Hypertension, Pulmonary; Lung; Gestational Age
Keywords
Bronchopulmonary dysplasia; Diagnosis; Management; Pathogenesis; Pulmonary hypertension
Recommended Citation
El-Saie A, Varghese NP, Webb MK, et al. Bronchopulmonary dysplasia - associated pulmonary hypertension: An updated review. Semin Perinatol. 2023;47(6):151817. doi:10.1016/j.semperi.2023.151817
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