Comprehensive Urine Drug Screen by Gas Chromatography-Mass Spectrometry (GC-MS).
Document Type
Article
Publication Date
2024
Identifier
DOI: 10.1007/978-1-0716-3541-4_22
Abstract
Drug screening is an important diagnostic tool in patient management and is an indispensable part of clinical toxicology laboratory services. While some laboratories employ automated chemistry analyzers for limited screening of drugs of abuse and a few common over-the-counter drugs, more comprehensive and detailed drug screening is needed for better patient care. Comprehensive drug screening generally involves immunoassays, colorimetric tests, and gas or liquid chromatography-mass spectrometry. Mass spectrometry is widely regarded as the gold standard for comprehensive drug screening due to its ability to detect hundreds of drugs. In this chapter, we present an efficient and rapid gas chromatography-mass spectrometry (GC-MS) method for comprehensive drug screening of urine samples. This method involves a liquid-liquid sample extraction, sample concentration, and subsequent analysis using GC-MS.
Journal Title
Methods in molecular biology (Clifton, N.J.)
Volume
2737
First Page
249
Last Page
256
Keywords
Comprehensive drug screening; Drug screening; Drugs of abuse; GC/MS
Recommended Citation
Ramoo B, Clinton Frazee C 3rd, Garg U. Comprehensive Urine Drug Screen by Gas Chromatography-Mass Spectrometry (GC-MS). Methods Mol Biol. 2024;2737:249-256. doi:10.1007/978-1-0716-3541-4_22
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