Pneumonia vaccine response in individuals with Down syndrome at three specialty clinics.
Document Type
Article
Publication Date
12-2023
Identifier
DOI: 10.1002/ajmg.c.32070
Abstract
Individuals with Down syndrome (DS) have been particularly impacted by respiratory conditions, such as pneumonia. However, the description of co-occurring recurrent infections, the response to pneumococcal immunization, and the association of these was previously unknown. We screened individuals with DS using an 11-item screener and prospectively collected pneumococcal titers and laboratory results. We found that the screener did not successfully predict which individuals with DS who would have inadequate pneumococcal titers. Thirty four of the 55 individuals with DS (62%) had abnormal pneumococcal titers demonstrating an inadequate response to routine immunization. In the absence of a valid screener, clinicians should consider screening all individuals with DS through the use of pneumococcal titers to 23 serotypes to assess vaccine response.
Journal Title
American journal of medical genetics. Part C, Seminars in medical genetics
Volume
193
Issue
4
First Page
32070
Last Page
32070
MeSH Keywords
Humans; Down Syndrome; Antibodies, Bacterial; Streptococcus pneumoniae; Pneumococcal Vaccines; Pneumonia
Keywords
Down syndrome; pneumonia; trisomy 21; vaccination
Recommended Citation
Santoro SL, Baloh CH, Hart SJ, et al. Pneumonia vaccine response in individuals with Down syndrome at three specialty clinics. Am J Med Genet C Semin Med Genet. 2023;193(4):e32070. doi:10.1002/ajmg.c.32070
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