Future Directions of Allergen Immunotherapy for Allergic Rhinitis: Experts' Perspective.

Document Type

Article

Publication Date

1-2024

Identifier

DOI: 10.1016/j.jaip.2023.08.047

Abstract

Allergen immunotherapy (AIT) is broadly used all over the world as the only available disease-modifying treatment option. The aim of this experts' perspective is to address 7 important unmet needs for the further direction of AIT and to provide the readership with the authors' positions on these topics. An international group of experts in the field of AIT have formulated 7 important aspects for the future position of AIT, performed a current literature review, and proposed a consented position on these topics. The aspects discussed and consented by the authors include: (1) alternative routes of allergen application in AIT, (2) potential of recombinant vaccines, (3) the role of allergy diagnosis based on component-resolved diagnosis for AIT composition, (4) the impact of COVID-19 vaccination for further innovations in AIT, (5) potential of combining biologics to AIT, (6) future innovations in high-risk children/adolescents, and (7) the future regulatory position on AIT. Important unmet needs and topics for AIT have been addressed in this expert review. The authors' views and personal position on these 7 aspects have also been elaborated.

Journal Title

J Allergy Clin Immunol Pract

Volume

12

Issue

1

First Page

32

Last Page

44

MeSH Keywords

Child; Adolescent; Humans; COVID-19 Vaccines; Rhinitis, Allergic; Desensitization, Immunologic; Allergens; Forecasting

Keywords

Allergen immunotherapy; Allergic rhinitis; Future; Intralymphatic immunotherapy; Recombinants; Regulatory

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