BrAIST-Calc: Prediction of Individualized Benefit From Bracing for Adolescent Idiopathic Scoliosis.

Document Type

Article

Publication Date

2-1-2024

Identifier

DOI: 10.1097/BRS.0000000000004879

Abstract

STUDY DESIGN: Prospective multicenter study data were used for model derivation and externally validated using retrospective cohort data.

OBJECTIVE: Derive and validate a prognostic model of benefit from bracing for adolescent idiopathic scoliosis (AIS).

SUMMARY OF BACKGROUND DATA: The Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST) demonstrated the superiority of bracing over observation to prevent curve progression to the surgical threshold; 42% of untreated subjects had a good outcome, and 28% progressed to the surgical threshold despite bracing, likely due to poor adherence. To avoid over-treatment and to promote patient goal setting and adherence, bracing decisions (who and how much) should be based on physician and patient discussions informed by individual-level data from high-quality predictive models.

MATERIALS AND METHODS: Logistic regression was used to predict curve progression to < 45° at skeletal maturity (good prognosis) in 269 BrAIST subjects who were observed or braced. Predictors included age, sex, body mass index, Risser stage, Cobb angle, curve pattern, and treatment characteristics (hours of brace wear and in-brace correction). Internal and external validity were evaluated using jackknifed samples of the BrAIST data set and an independent cohort (n=299) through estimates of discrimination and calibration.

RESULTS: The final model included age, sex, body mass index, Risser stage, Cobb angle, and hours of brace wear per day. The model demonstrated strong discrimination ( c -statistics 0.83-0.87) and calibration in all data sets. Classifying patients as low risk (high probability of a good prognosis) at the probability cut point of 70% resulted in a specificity of 92% and a positive predictive value of 89%.

CONCLUSION: This externally validated model can be used by clinicians and families to make informed, individualized decisions about when and how much to brace to avoid progression to surgery. If widely adopted, this model could decrease overbracing of AIS, improve adherence, and, most importantly, decrease the likelihood of spinal fusion in this population.

Journal Title

Spine (Phila Pa 1976)

Volume

49

Issue

3

First Page

147

Last Page

156

MeSH Keywords

Humans; Adolescent; Scoliosis; Retrospective Studies; Prospective Studies; Prognosis; Braces; Treatment Outcome; Disease Progression

Keywords

Scoliosis; Retrospective Studies; Prospective Studies; Prognosis; Braces; Treatment Outcome; Disease Progression

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