Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections.
Document Type
Article
Publication Date
2-1-2024
Identifier
DOI: 10.1097/MAT.0000000000002059
Abstract
Outcomes of pediatric patients who received extracorporeal life support (ECLS) for COVID-19 remain poorly described. The aim of this multi-institutional retrospective observational study was to evaluate these outcomes and assess for prognostic factors associated with in-hospital mortality. Seventy-nine patients at 14 pediatric centers across the United States who received ECLS support for COVID-19 infections between January 2020 and July 2022 were included for analysis. Data were extracted from the electronic medical record. The median age was 14.5 years (interquartile range [IQR]: 2-17 years). Most patients were female (54.4%) and had at least one pre-existing comorbidity (84.8%), such as obesity (44.3%, median body mass index percentile: 97% [IQR: 67.5-99.0%]). Venovenous (VV) ECLS was initiated in 50.6% of patients. Median duration of ECLS was 12 days (IQR: 6.0-22.5 days) with a mean duration from admission to ECLS initiation of 5.2 ± 6.3 days. Survival to hospital discharge was 54.4%. Neurological deficits were reported in 16.3% of survivors. Nonsurvivors were of older age (13.3 ± 6.2 years vs. 9.3 ± 7.7 years, p = 0.012), more likely to receive renal replacement therapy (63.9% vs. 30.2%, p = 0.003), demonstrated longer durations from admission to ECLS initiation (7.0 ± 8.1 days vs. 3.7 ± 3.8 days, p = 0.030), and had higher rates of ECLS-related complications (91.7% vs. 69.8%, p = 0.016) than survivors. Pediatric patients with COVID-19 who received ECLS demonstrated substantial morbidity and further investigation is warranted to optimize management strategies.
Journal Title
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Volume
70
Issue
2
First Page
146
Last Page
153
MeSH Keywords
Humans; Child; Female; Child, Preschool; Adolescent; Male; Extracorporeal Membrane Oxygenation; COVID-19; Retrospective Studies; Hospitalization; Hospital Mortality
Keywords
Extracorporeal Membrane Oxygenation; COVID-19; Retrospective Studies; Hospitalization; Hospital Mortality
Recommended Citation
Jacobson JC, Ryan ML, Vogel AM, et al. Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections. ASAIO J. 2024;70(2):146-153. doi:10.1097/MAT.0000000000002059
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